"But nobody today can say that one does not know what cancer and its prime cause be. On the contrary, there is no disease whose prime cause is better known, so that today ignorance is no longer an excuse that one cannot do more about prevention. That prevention of cancer will come there is no doubt, for man wishes to survive. But how long prevention will be avoided depends on how long the prophets of agnosticism will succeed in inhibiting the application of scientific knowledge in the cancer field. In the meantime, millions of men must die of cancer unnecessarily." ~ Nobel Prize Winner Otto Warburg in a meeting of Nobel Laureates, June 30, 1966

Saturday, July 13, 2013

CANCER GENE (BRCA1) (BRCA2)

Natural Compound Prevents Breast Cancer Gene (BRCA1) Malignancy…. It’s Not IN The Genes So Much As WHAT You Expose Them To

There is so much fear and misinformation surrounding the so-called ‘Breast Cancer Associated’ genes, BRCA1 and BRCA2, that it should help to dispel some prevailing myths by looking at the crucial role that epigenetic factors play in their expression. Literally ‘above’ (epi) or ‘beyond’ the control of the genes, these factors include environmental chemical exposures, nutrition and stress, which profoundly affect cancer risk within us all, regardless of what variant (‘mutated’ or ‘wild’)* that we happen to carry within our genomes.

In 2012, a very important study was published in the Journal of Nutritional Biochemistry that looked at the role a natural compound called resveratrol may play in preventing the inactivation of the BRCA-1 gene.

BRCA-1 is known as a “caretaker” gene because it is responsible for healing up double-strand breaks within our DNA. When the BRCA-1 gene is rendered dysfunctional or becomes inactivated, either through a congenital/germline inheritance of DNA defects (‘mutation’) or through chemical exposures, the result is the same: harm to the DNA repair mechanisms within the affected cells (particularly breast and ovary; possibly testicular), hence increasing the risk of cancer.

Ironically, while the prevalence of a “bad” inherited BRCA1 variation is actually quite low relative to the general population (a 2003 study found only 6.6% of breast cancer patients even have either a BRCA1 and BRCA2 germline mutation [1] ), everyone’s BRCA1 and BRCA2 genes are susceptible to damage from environmental chemical exposures, most particularly xenobiotic (non-natural) chemicals and radiation. This means that instead of looking to a set of “bad” genes as the primary cause of cancer, we should be looking to avoid exposing both our “bad” and “good” genes alike to preventable chemical exposures, as well as avoiding nutrient deficiencies and/or incompatibilities, which also play a vital role in enabling us to express or silence cancer-associated genes.

[For more on why genes don't "cause" disease see: The Great DNA Data Deficit on GreenMedInfo]

Natural Compound Prevents Breast Cancer Gene (BRCA1) Malignancy


Quite a mouthful.

Essentially, the BRCA-1 promoter is the gene sequence within the BRCA1 gene that drives the production of the protein that enables our cells to repair DNA damage, and when “silenced” (ie. hypermethylated) via the receptor for aromatic hydrocarbons (which are primarily xenobiotic petrochemical compounds), it leads to chromosomal damage within those cells. This study looked at the role of resveratrol, a natural compound found in grapes, wine, chocolate, and peanuts, in preventing these chemically-induced changes in gene methylation, also known as ‘gene silencing.’

According to the study:
“The aberrant hypermethylation of tumor suppressor genes has been recognized as a predisposing event in breast carcinogenesis [1]. For example, BRCA-1 promoter hypermethylation has been linked to loss or silencing of BRCA-1 expression in sporadic breast tumors [2–7] and the development of high-grade breast carcinomas [8–10].
Higher incidence (30%–90%) of BRCA-1 hypermethylation has been reported in infiltrating tumors [2,10–12], suggesting that epigenetic repression of BRCA-1 may accompany the transition to more invasive phenotypes. Moreover, BRCA-1 promoter methylation was found to be positively associated with increased mortality among women with breast cancer [13].
The researchers went on to test resveratrol’s ability to prevent BRCA-promoter inactivation caused by the persistent environmental pollutant 2,3,7,8 tetrachlorodibenzo-p-dioxin (TCDD), which has been linked to birth defects, cancer, immune suppression, liver damage and endocrine disruption, and has been found distributed throughout the global food supply, and even in breast milk.

Resveratrol was found to prevent TCDD-induced suppression of BRCA-1 expression. They discovered that resveratrol was capable of suppressed the silencing (hypermethylation) of the BRCA-1 promoter, revealing one of several possible mechanisms for its well-known anti-cancer properties, including 19 studies on GreenMedInfo.com alone on its anti-breast cancer potential.[2]

Breast Cancer 2 

Resveratrol is only one of a wide range of natural, food-derived compounds which possess the ability to bind and interact as ligands with the aromatic hydrocarbon receptor (AhR) within the cells of our body. Curcumin, the primary polyphenol in the spice turmeric, for instance, has been found to induce programmed cell death in triple negative breast cancer cells, in part through modulating BRCA1 protein expression and levels within the cytoplasm of normal and cancerous cells.

The researchers concluded “The fact that many food constituents possess ligand properties towards the AhR [57,58] may offer new avenues for the development of prevention strategies for the prevention of BRCA-1 silencing in sporadic breast tumors.”

This is a fancy way of saying that we can prevent chemically-induced cancers through including and perhaps increasing the level of phytoactive, chemopreventive compounds within our diet; and of course, reducing and if possible eliminating chemical exposures that ‘knock out’ the BRCA1/BRCA2 gene function in way that leads to cancer.

This, and not some gene-based future drug therapy, is where researchers and medical practitioners should be ‘racing’ for their long sought-after solution. Remove the cause. Prevent and cure the disease.

For a list of 249 other natural substances that have experimentally confirmed anti-breast cancer activity visit GreenMedInfo’s Breast Cancer research page, as well as GreenMedInfo’s Health Guide: Breast Cancer.

Resources:
[1] Silvia de Sanjosé, Mélanie Léoné, Victoria Bérez, Angel Izquierdo, Rebeca Font, Joan M Brunet, Thierry Louat, Loreto Vilardell, Joan Borras, Pau Viladiu, F Xavier Bosch, Gilbert M Lenoir, Olga M Sinilnikova. Prevalence of BRCA1 and BRCA2 germline mutations in young breast cancer patients: a population-based study. Int J Cancer. 2003 Sep 10 ;106(4):588-93. PMID: 12845657
[2] GreenMedInfo.com, Reseveratrol’s Anti-Breast Cancer Properties (19 abstracts)
*We looked at the theoretical problems associated with BRCA1/BRCA2-mediated disease causation in the article: Did Angelina Jolie Make A Mistake By Acting On the Gene Theory of Breast Cancer?
Further articles by Sayer Ji
About the author:
Sayer-JiSayer Ji is the founder and director of www.GreenMedInfo.com and an advisory board member at the National Health Federation, an international nonprofit, consumer-education, health-freedom organization.
He co-authored the book Cancer Killers: The Cause Is The Cure, and is currently co-authoring another book with Tania Melkonian entitled EATomology: An Edible Philosophy of Food.
Check out Sayer Ji’s new collaborative project EATomology.



1 comment:

  1. My name is Perry and my father has been suffering from lung cancer and the doctor told us that there is nothing he could do after doing 5 times chemotherapy and radiation and my father was not responding to treatment and not getting better.i was frustrated and confused and seeking advice from people until a friend told me about Dr. Koffi herbal cannabis oil and its fast curing ability of any kind of cancer and told me that her mother ovarian cancer was cured with the cannabis oil. I was desperate to save my father and i contacted Dr. Koffi via email to get the miraculous oil. As i am writing this testimony on this Blog my father is so strong and healthy no more cancer in his cell blood again.my Father has been his self and i am so excited of his fast recovery and with the help of this oil. What a miracle. My Father is now back alive, strong and health just within 3 weeks. We have gone for test and the doctor said no trance of cancer again.

    You Can Contact Dr. Koffi on: Ultimatecancercure@yahoo.com
    Website:http://ultimatecancercure.wixsite.com/drkoffi
    Call +1 908-652-3147 .....

    ReplyDelete